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Volume 10, Issue 1 (2-2024)
jhehp 2024, 10(1): 18-23 |
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Mofid V, Peivasteh-roudsari L, Karami H, Tajdar-oranj B, Mirza Alizadeh A, Karami M et al . Probabilistic Health Risk Assessment of Aflatoxin M1 in Pasteurized Milk from Different Cities of Iran. jhehp 2024; 10 (1) :18-23
URL: http://jhehp.zums.ac.ir/article-1-619-en.html
URL: http://jhehp.zums.ac.ir/article-1-619-en.html
Vahid Mofid1 
, Leila Peivasteh-roudsari2 , Hadis Karami3 , Behrouz Tajdar-oranj4 , Adel Mirza Alizadeh5 , Marziyeh Karami3 , Anosheh Rahmani *6
, Leila Peivasteh-roudsari2 , Hadis Karami3 , Behrouz Tajdar-oranj4 , Adel Mirza Alizadeh5 , Marziyeh Karami3 , Anosheh Rahmani *6
1- Department of Food Science and Technology, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Food and Drug Administration of Iran, Ministry of Health and Medical Education, Tehran, Iran.
3- Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
4- Nutrition Sciences and Food Technology Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran.
5- Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
6- Department of Food, Halal and Agricultural Products, Food Technology and Agricultural Products Research Center, Standard Research Institute (SRI), Karaj, Iran.
2- Food and Drug Administration of Iran, Ministry of Health and Medical Education, Tehran, Iran.
3- Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
4- Nutrition Sciences and Food Technology Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran.
5- Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
6- Department of Food, Halal and Agricultural Products, Food Technology and Agricultural Products Research Center, Standard Research Institute (SRI), Karaj, Iran.
Abstract: (1640 Views)
Background: The presence of Aflatoxin M1 (AFM1) in dairy products results from the ingestion of feedstuffs contaminated with aflatoxin B1 by ruminants. The current study aimed to determine the AFM1 concentration in commercial pasteurized cow milk samples obtained from the Iranian market.
Methods: A total of 54 pasteurized cow milk samples, manufactured between January and April 2019, were purchased from different cities in Iran, including Tehran, Isfahan, Sari, Tabriz, Zanjan, Kermanshah, Ahvaz, Shiraz, and Kerman. These samples were analyzed using a competitive enzyme-linked immune-sorbent assay technique. The associated health risk was estimated by the Monte Carlo simulation method. Additionally, the margin of exposure and cancer risk were employed as benchmarks to assess threats to consumer health.
Results: AFM1 was detected in 33 samples (61 %), totally with concentrations ranging from 0.003 to 0.45 µg kg-1. 9.26 % of the samples exceeded the maximum residue level specified by Iran's national standard (0.1 µg kg-1). The average concentration of AFM1 in the 54 pasteurized milk samples collected from different regions was determined to be 0.042 ± 0.072 µg L-1. Nevertheless, all samples remained below the US Food and Drug Administration (USFDA) maximum limit (0.5 µg kg-1). Human health risk assessment showed that about half of the consumers were at risk based on the Margin of Exposure (MOE) assessment.
Conclusion: The results of this survey indicate the usefulness of a monitoring program to supervise the safety of commercially available pasteurized cow milk for consumers.
Methods: A total of 54 pasteurized cow milk samples, manufactured between January and April 2019, were purchased from different cities in Iran, including Tehran, Isfahan, Sari, Tabriz, Zanjan, Kermanshah, Ahvaz, Shiraz, and Kerman. These samples were analyzed using a competitive enzyme-linked immune-sorbent assay technique. The associated health risk was estimated by the Monte Carlo simulation method. Additionally, the margin of exposure and cancer risk were employed as benchmarks to assess threats to consumer health.
Results: AFM1 was detected in 33 samples (61 %), totally with concentrations ranging from 0.003 to 0.45 µg kg-1. 9.26 % of the samples exceeded the maximum residue level specified by Iran's national standard (0.1 µg kg-1). The average concentration of AFM1 in the 54 pasteurized milk samples collected from different regions was determined to be 0.042 ± 0.072 µg L-1. Nevertheless, all samples remained below the US Food and Drug Administration (USFDA) maximum limit (0.5 µg kg-1). Human health risk assessment showed that about half of the consumers were at risk based on the Margin of Exposure (MOE) assessment.
Conclusion: The results of this survey indicate the usefulness of a monitoring program to supervise the safety of commercially available pasteurized cow milk for consumers.
Type of Study: Original Article |
Subject:
Food Safety and Hygiene
Received: 2023/12/10 | Accepted: 2024/01/20 | Published: 2024/02/7
Received: 2023/12/10 | Accepted: 2024/01/20 | Published: 2024/02/7
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