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jhehp 2025, 11(1): 19-26 |
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Shahbazi K, Jameshorani M, Mahmoodkhani A, Mousavi S N. Dietary Inflammatory and Glycemic Indices in Newly Diagnosed Irritable Bowel Syndrome Patients Compared to Healthy People: A Case-Control Study. jhehp 2025; 11 (1) :19-26
URL: http://jhehp.zums.ac.ir/article-1-667-en.html
URL: http://jhehp.zums.ac.ir/article-1-667-en.html
1- Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
2- Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
2- Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Abstract: (134 Views)
Methods: A total of 161 newly diagnosed IBS patients, identified according to the Rome IV criteria, and 163 healthy controls (aged ≥ 18 years) participated in the study. The dietary inflammatory index (DII), glycemic index (GI), and glycemic load (GL) were computed based on a 168-item food frequency questionnaire.
Results: After adjusting for baseline parameters, total DII showed a significant effect on the risk of IBS (OR = 0.41, 95% CI = 0.268, 0.62; P < 0.001). Participants in the last quartile of DII showed a 3.8-fold increased risk of IBS compared to those in the lowest quartile (95% CI = 1.92, 7.6; p < 0.001). In addition, a higher dietary total GL increased the risk of IBS by 52% (95% CI = 0.34-0.64, p < 0.001). Moreover, patients in the highest quartile of dietary GL showed a 21.7-fold greater risk of IBS compared to those in the lowest quartile (p < 0.001). An increase in lactose and fructose intake increased the risk of IBS by 10% (p = 0.03) and 13% (p = 0.01), respectively. Conversely, higher fiber intake decreased the risk of IBS by 11% (p = 0.04).
Conclusion: This study showed a possible positive association between diets characterized by high DII and GL and the risk of IBS.
Type of Study: Original Article |
Subject:
Public Health
Received: 2024/11/2 | Accepted: 2024/12/25 | Published: 2025/01/13
Received: 2024/11/2 | Accepted: 2024/12/25 | Published: 2025/01/13
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