en Food Safety and Hygiene Food Safety and Hygiene Review Review Article <div style="text-align: justify;"><span style="line-height:1;"><span style="font-size:14px;"><span style="font-family:Times New Roman;">Solanine, a steroidal glycoside found in potatoes, serves as a natural defense mechanism for the plant, exhibiting fungicidal and pesticidal properties that protect it from phytopathogenic fungi. This compound can be present in various parts of the plant, including the leaves, fruits, and tubers. However, control measures on solanum glycoside toxins are based on careful selection and seed potato varieties, and attention to handling and processing. In order to reduce the risks and ensure sustainable storage, potatoes should be stored in cool, dark areas. Solanine poisoning is primarily manifested by gastrointestinal and neurological disorders and may cause severe nervous and exanthematous syndrome. This review provides a comprehensive survey on glycoalkaloid distribution in potatoes and its associated factors, its impact on flavor, the neurotoxic effects of solanine on humans, the various analytical methods used for its evaluation, and strategies to control its formation.</span></span></span></div> Solanine, Solanum tuberosum, Solanaceous Alkaloids, Alpha-chaconine, Neurotoxicity syndromes, 25 35 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-268-3&slc_lang=en&sid=1 Mina Saei mina.saei89@gmail.com 100319475328460016221 0009-0003-2676-0147 No Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Naiema Vakili Saatloo vakili.naeima@gmail.com 100319475328460016222 100319475328460016222 No Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran. Parisa Shavali-Gilani shahvali@gmail.com 100319475328460016223 100319475328460016223 No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Nastaran Akbariyeh Akbariyenastaran@yahoo.com 100319475328460016224 0009-0003-5999-613X No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Cheraghian cheraghianf@yahoo.com 100319475328460016225 0009-0004-7652-1029 No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Leila Haji hajileila@yahoo.com 100319475328460016226 100319475328460016226 No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Parisa Sadighara parisasss@yahoo.com 100319475328460016227 100319475328460016227 No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Tayebeh Zeinali ta.zeinali@bums.ac.ir 100319475328460016228 100319475328460016228 Yes Department of Nutrition and Food Hygiene, School of Health, Geriatric Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.