en Environmental Health, Sciences, and Engineering Environmental Health, Sciences, and Engineering Review Review Article <div><span style="line-height:1;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b><span style="color:black">Background:</span></b><span style="color:black"> Plants produce a diverse array of natural compounds including primary and secondary metabolites.</span> <span style="color:black">Primary metabolites, such as those involved in photosynthesis,</span> <span style="color:black">contribute to plant growth development. Secondary metabolites, on the other hand, play crucial roles in plant defense, signaling, and the production of medically important compounds. These secondary metabolites not only contribute to the aromatic properties of plants but also possess therapeutic potential. Furthermore, they play a multifaceted role in the plant&#39;s adaptation to various environmental stresses. This study aims to provide a comprehensive review to guide future clinical research on the medicinal applications of plant-derived compounds. </span><span dir="RTL" lang="FA"><span style="color:black"></span></span><br> <b><span style="color:black">Methods: </span></b><span style="color:black">We conducted a detailed review of 38 articles and provided a thorough summary of our findings in this section.</span><br> <b><span style="color:black">Results: </span></b><span style="color:black">The utilization of medicinal plants has evolved over time. Initially, they were used solely for their medicinal properties, but subsequently, they have become the subject of extensive clinical research for the treatment of various diseases using their extracted compounds.</span><br> <b><span style="color:black">Conclusion: </span></b><span style="color:black">We suggest that researchers conduct clinical studies on the synergistic effect of natural plant compounds and explore the development of recombinant drugs for the treatment of a wide range of diseases.</span></span></span></span></div> Medicinal plants, Secondary metabolites, Natural compounds, Primary metabolites, Clinical studies, 191 198 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-576-2&slc_lang=en&sid=1 Sahebeh Hajipour saheb.hpr@gmail.com 100319475328460015705 100319475328460015705 No Department of Biology, Faculty of Science, Golestan University, Golestan, Iran. Ali Ghonoudi Ghonodi2380@gmail.com 100319475328460015706 0009-0001-6788-3472 No Department of Pharmacy, Faculty of Pharmacy, University of Tehran, Tehran, Iran. Ebrahim Alinia-Ahandani Dr.ebrahim.alinia@es.isfpnu.ac.ir 100319475328460015707 100319475328460015707 Yes Deputy of Food and Drug, Guilan University of Medical Sciences, Rasht, Iran. Ammara Riaz ammara.riaz@kfueit.edu.pk 100319475328460015708 100319475328460015708 No Department of Life Sciences, Khwaja Fareed University of Engineering and Information Technology Rahimyar Khan, Pakistan.