en Environmental Health, Sciences, and Engineering Environmental Health, Sciences, and Engineering پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:1;"><b>Background:</b> Proper management of hospital waste is crucial for maintaining public health and ensuring biosafety. Given the importance of personnel in this area and the need to evaluate the current situation, this study aimed to assess the knowledge, attitude, and practice (KAP) of staff at Imam Ali Hospital in Sarayan, Iran, regarding hospital waste management.<br> <b>Methods:</b> This descriptive-analytical cross-sectional study was conducted in 2024 among 95 staff members of Imam Ali Hospital in Sarayan, Iran, using a full census approach. Data were collected using a validated 44-item questionnaire assessing KAP regarding hospital waste management. Following assessment of data normality, Spearman&rsquo;s correlation coefficient, Mann&ndash;Whitney U test, and Kruskal&ndash;Wallis test were used for statistical analysis.<br> <b>Results:</b><b> </b>The mean scores for KAP were 10.43 &plusmn; 2.14, 38.39 &plusmn; 5.28, and 8.66 &plusmn; 2.87, respectively, indicating moderate levels across all domains. A significant positive correlation was observed among KAP, with the strongest correlation identified between knowledge and practice (r = 0.702, <i>p</i> < 0.001). However, awareness of the national medical waste management law was notably low (31.9%). Participation in training programs was associated with significantly higher knowledge and practice scores (<i>p</i> < 0.05).<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span><br> <b>Conclusion:</b> The present study demonstrates that hospital personnel possess a reasonably acceptable level of knowledge and attitude towards waste management. The study also highlights the significant relationship between knowledge and practice, as well as the positive influence of training courses on both.</span></span></span></div> Hospital waste, Knowledge, Attitude, Practice, Hospital personnel, 0 0 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-704-1&slc_lang=en&sid=1 Senobar Imanian emaniansenobar@gmail.com 100319475328460016799 100319475328460016799 No Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. Malihe Ram rammalihe@yahoo.com 100319475328460016800 100319475328460016800 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. Fatemeh Samiei fatemehsamiei13733@gmail.com 100319475328460016801 100319475328460016801 No Department of Environmental Health Engineering, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh Fanaei farzaneh.fanaei@bums.ac.ir 100319475328460016802 100319475328460016802 Yes Department of Environmental Health Engineering, Ferdows Faculty of Medical Sciences, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Masoumeh Heravi masoumheravi@gmail.com 100319475328460016803 0009-0008-9975-3155 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. Mahla Abbasi abbsii2001@gmail.com 100319475328460016804 0009-0004-1195-910X No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.