en Public Health Public Health Review Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:normal">Awareness of&nbsp; COVID-19 infection, as a public crisis, makes an emergency condition for survivors. Regarding the importance of early rehabilitation, we should pay particular attention to the potential risk of real-life toxicants in COVID-19 survivors. The adverse effects underlying COVID-19 infection lead to persistent sequelae in survivors. In addition, complete rehabilitation is challenging in seriously-ill patients due to cytokine storm severity, inflammation, oxidative stress, and cell death contributing to multi-organ damage. Different foods, environmental/occupational pollutants, and unhealthy lifestyles are real-life examples of toxicants that can pose redox imbalance and oxidative damage to the biological system. The key concept is that survived patients with persistent tissue damage, low-grade inflammation, oxidative stress, and fibrosis are susceptible to real-life toxic stressors, which have the potential for oxidative stress. Moreover, fibrosis are susceptible to toxic stressors, which can induce harmful effects by promoting oxidative stress and pro-inflammatory components. This paper attempted to elucidate a vital toxicological concept in which the existing sequelae of COVID-19 survivors increase the potential risk of real-life toxicants and to propose a practical strategic approach to reduce toxicant exposure.</span><br> <span style="line-height:107%"><b>Abbreviation:</b><b> </b>Lipid radical (L&bull;), Lipid peroxyl radical (LOO&bull;), Lipid alkoxyl radical (LO&bull;), particulate matter (PM), reactive oxygen species (ROS), ultra-fine particle (UFP).</span></span></span> Toxicant, COVID-19 survivor, Oxidative stress, Risk management, 69 76 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-385-1&slc_lang=en&sid=1 Rana Dizaji rana.dizaji@yahoo.com 100319475328460012009 0000000168123902 Yes Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.