en Environmental Health, Sciences, and Engineering Environmental Health, Sciences, and Engineering پژوهشي Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:normal"><b><span style="color:black">Background:</span></b> <span style="color:black">This study evaluated the Antibiotic Resistant Pattern and Multiple Antibiotic Index of multidrug-resistant S. aureus from wound infection patients in Federal Medical Center Umuahia, Abia State. </span></span><br> <span style="line-height:normal"><b><span style="color:black">Methods:</span></b> <span style="color:black">A total of 300 wound swab samples from diabetic leg ulcers, accident wounds, burn wounds and surgical site wounds were collected from different wards and cultured on Blood agar and Mannitol Salt agar. </span></span><br> <span style="line-height:normal"><b><span style="color:black">Results:</span></b><b> </b><span style="color:black">S. aureus was isolated from 50 (16.7%) samples, of which, 14 (28%) were diabetic leg ulcers, 11 (22%) accident wounds, 16 (32%) burn wounds, and 9 (18%) surgical site wounds. There was no significant difference (P>0.05) in the different wards and sites of collection and between age and those with highly resistant S. aureus.&nbsp; The antimicrobial resistance profile of the isolates in the study samples from wound swabs and surgical site wounds was highest in amoxicillin (100%), erythromycin (100%), and Norfloxacin (100%). The overall prevalence of methicillin-resistant Staphylococcus aureus was 14.0%, while 66% of the S.aureus was multidrug-resistant. Multiple antibiotic resistance index from the study was between 0.4 - 0.6. </span></span><br> <span style="line-height:normal"><b><span style="color:black">Conclusion:</span></b> <span style="color:black">Antibiotic susceptibility testing should be performed before treatment and adequate measures should be taken.</span></span></span></span> Antibiotic Resistance, S. aureus, Multidrug-resistant, Multiple Antibiotic Resistance Index, Wound Infection, 77 82 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-520-1&slc_lang=en&sid=1 Joan Miracle James-Onyekwere joanjamesonyekwere@gmail.com 100319475328460012014 0000000286565189 Yes Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. Immaculata Ugochi Nwankwo immaugo@yahoo.com 100319475328460012015 0000000167245449 No Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. Ebubechi Uloma Okey-kalu ulomamgbeokwere@yahoo.com 100319475328460012016 0000000248723801 No Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.