en Environmental Health, Sciences, and Engineering Environmental Health, Sciences, and Engineering پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><strong>Background:</strong> The present study aimed to determine the concentrations of cadmium (Cd) and lead (Pb) in water, bottom sediments, and tissues of sampled fish from Mellat artificial lake in Iran<span dir="RTL">.</span><br> <strong>Methods: </strong>Two stations were selected to evaluate the heavy metal concentrations, including the IRIB qanat (S1) and middle part of the lake (S2). The measurements were performed in triplicate via flame atomic absorption spectroscopy<span dir="RTL">.</span><br> <strong>Results:</strong> In water, the highest levels of Pb (5.33 mg/l) and Cd (0.650 mg/l) were observed in the sampled sediments from S2 in autumn and winter, respectively (<em>P </em>< 0.05). Seasonal analysis revealed that the highest and lowest Pb concentrations were in the fish muscles in summer (8.107 mg/kg) and spring (0.487 mg/kg), respectively, while the fish liver showed the maximum (3.982 mg/kg) and minimum Pb concentrations (0.690 mg/kg) in autumn and winter, respectively. The Pb concentration in the fish muscle and liver was above the standard limits for human consumption. However, the Cd level in the fish muscle in spring was below the standard limits, which gradually increased and exceeded the standard limits<span dir="RTL">.</span><br> <strong>Conclusion:</strong> Precautions are required to avoid the contamination of Mellat Lake with heavy metal-based sources due to the discharge of pollutants.</span></span></div> Mellat lake,Cadmium,Lead,Heavy metals,Sediment 177 182 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-293-1&slc_lang=en&sid=1 Mehdi Shamsaie Mehrgan m.shamsaie@srbiau.ac.ir 10031947532846009781 10031947532846009781 Yes Department of Fisheries Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Seyed Pezhman Hosseini Shekarabi hosseini@srbiau.ac.ir 10031947532846009782 10031947532846009782 No Department of Fisheries Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Bahareh Hassanzadeh bahar.sh@gmail.com 10031947532846009783 10031947532846009783 No Department of Fisheries Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Seyed Hadi Seyed Alhosseini hadihossini774@yahoo.com 10031947532846009784 10031947532846009784 No Department of Fisheries, Faculty of Marine Natural Resources, Khorramshahr University of Marine Science and Technology, Khuzestan, Iran.