en Public Health Public Health پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><strong>Background:</strong> The rate of drug dependence and abuse is a growing problem in the Iran, number of opioid &ndash; dependent people is estimated at a total of 2000.000-4000.000 individuals. The aim of this study was a Comparison of Methadone and Buprenorphine in the Treatment of Opiate Addiction referring to a treatment clinic of Baharan psychiatric hospital in Zahedan city.<br> <strong>Methods: </strong>In a cross sectional study, 152 patients with opioid dependence were assigned into two treatment groups i.e. Methadone and Buprenorphine. Data were collected from patients using a questionnaire COWS. ANOVA and repeated measures regressions were used to evaluate the significant differences on using drug (methadone and Buprenorphine), time, and drug-by-time interaction terms.<br> <strong>Results:</strong> Patients on MMT and BMT differed in terms of Age started addiction (<em>P</em> = 0.0001); education level (<em>P </em>= 0.0001); and income (<em>P</em> = 0.0001), and no differed in term of sex (<em>P</em> = 0.8). There was no significant difference between the two groups taking buprenorphine and methadone (<em>P</em> = 0.87).<br> <strong>Conclusion: </strong>In conclusion, our study indicated, Buprenorphine and methadone are both proven to be effective treatment options.</span></span></div> Methadone, Buprenorphine, Opiate addiction 20 25 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-69-4&slc_lang=en&sid=1 Mahbobeh Firouzkouhi Moghaddam Firouzkouhi Moghaddam930@gmail.com 10031947532846009537 10031947532846009537 No Research Center for Health of Adolescents and Children, Zahedan University of Medical Sciences, Zahedan, Iran. Tayebeh Rakhshani healthacademic2014@gmail.com 10031947532846009538 10031947532846009538 Yes Nutrition Research Center , School of Health , Shiraz University of Medical Science ,Shiraz , Iran. Fariba Kadkhodaie Kadkhodaie 930@gmail.com 10031947532846009539 10031947532846009539 No Research Center for Health of Adolescents and Children, Zahedan University of Medical Sciences, Zahedan, Iran. Mostafa Rashki - 10031947532846009540 10031947532846009540 No Department of Public Health , School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.