en Occupational and Industrial Health Occupational and Industrial Health Review Review Article <div data-end="568" data-start="112" style="text-align: justify;"> <div class="WordSection1"><span style="line-height:1;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="page:WordSection1"><b><span style="color:black">Background:</span></b><span style="color:black"> Lead poisoning is a major public health concern due to its widespread presence and harmful health effects. This review summarizes evidence on the effectiveness of garlic in reducing blood lead levels, as well as its impact on oxidative stress and inflammatory markers associated with lead exposure.</span><span dir="RTL" lang="AR-SA"><span style="color:black"></span></span><br> <b><span style="color:black">Methods:</span></b><span style="color:black"> This narrative review searched PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library (2007&ndash;2024) using keywords related to garlic (Allium sativum) and lead toxicity. Only English-language experimental and clinical studies assessing garlic&rsquo;s effect on blood lead were included. Reviews, case reports, and unrelated articles were excluded.</span><span dir="RTL" lang="AR-SA"><span style="color:black"></span></span><br> <b><span style="color:black">Results:</span></b><span style="color:black"> Of 1,037 identified articles, 12 met inclusion criteria. Animal studies showed a 30&ndash;50% reduction in blood lead levels following garlic supplementation. Clinical studies demonstrated that 1,200 &mu;g of allicin-rich garlic, administered three times daily for four weeks, significantly reduced blood lead levels, with effects comparable to succimer and without notable adverse effects.</span><span dir="RTL" lang="AR-SA"><span style="color:black"></span></span><br> C<b><span style="color:black">onclusion:</span></b><span style="color:black"> This review indicates garlic is a potentially safe and effective method for reducing blood lead levels in experimental and clinical settings. Clinical trials reported some side effects but no serious effects at studied doses (e.g., 1200 &mu;g allicin three times daily for 4 weeks).</span></span></span></span></span><span style="page:WordSection1"><span style="font-size:9pt"><span style="line-height:normal"><span style="font-family:Gulliver"><span style="color:black"></span></span></span></span></span></div> <div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> <div style="text-align: justify;"></div> Garlic, Allium sativum, Lead toxicity, Oxidative stress, Inflammatory markers, 0 0 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-571-1&slc_lang=en&sid=1 Mehran Pourhossein mpourhossein@zums.ac.ir 100319475328460016360 100319475328460016360 Yes Department of Occupational Health Engineering, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran. Faegheh Amooei faeghehamooei@gmail.com 100319475328460016361 0009-0000-3561-9549 No Student Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran.