en Public Health Public Health پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><strong>Background: </strong>The present study aimed to determine the prevalence of thalassemia minor and sickle hemoglobin in marriage applicants referring to the Genetic Diseases Counseling Center of Kazeroun Health Center over 2014-2018<span dir="RTL">.</span><br> <strong>Methods: </strong>This cross-sectional study was conducted in Kazeroun, Iran. The statistical population included all couples referring to the marriage counseling centers in Kazeroun for pre-marriage tests during 2014-2018. In this study, the registration data associated with the health records of the couples seeking marriage counseling were used. <span dir="RTL"></span><br> <strong>Results: </strong>Over the years under scrutiny, 31114 applicants (15557 couples) referred to the health counseling center for marriage tests under the supervision of the health network. Among the marriage applicants, the highest prevalence of beta-thalassemia, alpha-thalassemia, anemia, sickle cell hemoglobin, and hemoglobinopathy was reported in 2014 (0.07), 2018 (0.15), 2014 (0.66), 2018 (0.9), and 2014 (0.05), respectively.<span dir="RTL"></span><br> <strong>Conclusion:</strong> The results of the present study showed that the prevalence of thalassemia and sickle cell anemia in Kazeroun over the study years was similar to that in other parts of Iran over the same years.</span></span></div> Prevalence, Thalassemia, Sickle cell anemia, Marriage applicants 183 187 http://jhehp.zums.ac.ir/browse.php?a_code=A-10-69-8&slc_lang=en&sid=1 Mohsen Moghadami moghaddami@gmail.com 10031947532846009785 10031947532846009785 No Non Communicable Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Masoud Sheybani sheybani930@gmail.com 10031947532846009786 10031947532846009786 No Community Education, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran. Abbas Reziaean Zadeh rezaiean@gmail.com 10031947532846009787 10031947532846009787 No Departemant of Epidemiology, Faculty of Public Health, Shiraz Univercity of Medical Science,Shiraz,Iran. Tayebeh Rakhshani healthacademic2014@gmail.com 10031947532846009788 10031947532846009788 Yes Nutrition Research Center , Department of Public Health, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran.