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Volume 12, Issue 2 (4-2026)
jhehp 2026, 12(2): 85-92 |
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Alinia-Ahandani E, Hajipour S, Shirani-Bidabadi B, Riaz A, Hosseinnejad S, Akram M et al . A Comprehensive Review of the Therapeutic Effects of Specific Medicinal Plants in the Treatment of Hypertension and Heart Attacks. jhehp 2026; 12 (2) :85-92
URL: http://jhehp.zums.ac.ir/article-1-709-en.html
URL: http://jhehp.zums.ac.ir/article-1-709-en.html
Ebrahim Alinia-Ahandani *1 
, Sahebe Hajipour2 , Behnaz Shirani-Bidabadi3 , Ammara Riaz4 , Saheb Hosseinnejad5 , Muhammad Akram6 , Amir Aris7
, Sahebe Hajipour2 , Behnaz Shirani-Bidabadi3 , Ammara Riaz4 , Saheb Hosseinnejad5 , Muhammad Akram6 , Amir Aris7
1- Food and Drug Research Center, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.
2- Department of Biology, Faculty of Science, Golestan University, Golestan, Iran.
3- Faculty of Biology, Islamic Azad University, Falavarjan Branch, Esfahan, Iran.
4- Department of Life Sciences, Khwaja Fareed University of Engineering and Information Technology Rahimyar Khan, Pakistan.
5- Faculty of Medicine, University of Szeged, Szeged, Hungary.
6- Department of Eastern Medicine, Government College University Faisalabad, Pakistan.
7- Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Department of Biology, Faculty of Science, Golestan University, Golestan, Iran.
3- Faculty of Biology, Islamic Azad University, Falavarjan Branch, Esfahan, Iran.
4- Department of Life Sciences, Khwaja Fareed University of Engineering and Information Technology Rahimyar Khan, Pakistan.
5- Faculty of Medicine, University of Szeged, Szeged, Hungary.
6- Department of Eastern Medicine, Government College University Faisalabad, Pakistan.
7- Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Abstract: (302 Views)
Background: Iran is rich in a diverse range of medicinal plants with significant potential for managing blood pressure. This review examines various plants, including black cumin, crataegus, garlic, lemon balm, and rose hips, which exhibit potential antihypertensive properties supported by scientific literature. The present study aimed to investigate the effect of secondary metabolites from Iranian medicinal plants on the treatment of various diseases, particularly hypertension and heart attacks, by examining their impacts on transcription factors and signaling pathways.
Methods: We reviewed 100 articles from clinical studies, of which 49 specifically addressed the impact of medicinal plants on blood pressure regulation. The primary database utilized was Google Scholar, focusing on articles with an impact factor exceeding 2. Selection criteria were established based on the relevance of secondary metabolites to blood pressure control.
Results: Medicinal compounds of plants, known as secondary metabolites, suppress cancer metastasis and inhibit a wide range of diseases, including blood pressure and heart attacks, through their effects on transcription factors and signaling pathways.
Conclusion: Clinical studies show that active compounds in plants, particularly black cumin, cause vasodilation and reduce blood pressure. In contrast to conventional antihypertensive medications, which are associated with significant side effects such as drug dependence and resistance, medicinal plants offer a promising alternative for alleviating disease symptoms through their effects on transcription factors.
Methods: We reviewed 100 articles from clinical studies, of which 49 specifically addressed the impact of medicinal plants on blood pressure regulation. The primary database utilized was Google Scholar, focusing on articles with an impact factor exceeding 2. Selection criteria were established based on the relevance of secondary metabolites to blood pressure control.
Results: Medicinal compounds of plants, known as secondary metabolites, suppress cancer metastasis and inhibit a wide range of diseases, including blood pressure and heart attacks, through their effects on transcription factors and signaling pathways.
Conclusion: Clinical studies show that active compounds in plants, particularly black cumin, cause vasodilation and reduce blood pressure. In contrast to conventional antihypertensive medications, which are associated with significant side effects such as drug dependence and resistance, medicinal plants offer a promising alternative for alleviating disease symptoms through their effects on transcription factors.
Type of Study: Review Article |
Subject:
Food Safety and Hygiene
Received: 2025/12/27 | Accepted: 2026/03/14 | Published: 2026/04/1
Received: 2025/12/27 | Accepted: 2026/03/14 | Published: 2026/04/1
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